Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions

Viruses

Saleh Eifan¹  Esther Schnettler²  Isabelle Dietrich²  Alain Kohl² 

[1] Department of Botany and Microbiology, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; E-Mail:;MRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, Scotland, UK; E-Mails:

关键词: arbovirus;    bunyavirus;    non-structural protein;    host response;    virus replication;   

DOI  :  10.3390/v5102447

来源: mdpi

【 摘 要 】

Viruses within the Bunyaviridae family are tri-segmented, negative-stranded RNA viruses. The family includes several emerging and re-emerging viruses of humans, animals and plants, such as Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, La Crosse virus, Schmallenberg virus and tomato spotted wilt virus. Many bunyaviruses are arthropod-borne, so-called arboviruses. Depending on the genus, bunyaviruses encode, in addition to the RNA-dependent RNA polymerase and the different structural proteins, one or several non-structural proteins. These non-structural proteins are not always essential for virus growth and replication but can play an important role in viral pathogenesis through their interaction with the host innate immune system. In this review, we will summarize current knowledge and understanding of insect-borne bunyavirus non-structural protein function(s) in vertebrate, plant and arthropod.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.