Genetic Characterization of Archived Bunyaviruses and their Potential for Emergence in Australia

Emerging Infectious Diseases

关键词: bunyavirus;    emergence;    arbovirus;    sequencing;    phylogenetics;    viruses;   

DOI  :  10.3201/eid2205.151566

来源: DOAJ

【 摘 要 】

To better understand the diversity of bunyaviruses and their circulation in Australia, we sequenced 5 viruses (Gan Gan, Trubanaman, Kowanyama, Yacaaba, and Taggert) isolated and serologically identified 4 decades ago as members of the family Bunyaviridae. Gan Gan and Trubanaman viruses almost perfectly matched 2 recently isolated, purportedly novel viruses, Salt Ash and Murrumbidgee viruses, respectively. Kowanyama and Yacaaba viruses were identified as being related to members of a large clade containing pathogenic viruses. Taggert virus was confirmed as being a nairovirus; several viruses of this genus are pathogenic to humans. The genetic relationships and historical experimental infections in mice reveal the potential for these viruses to lead to disease emergence.

【 授权许可】

Unknown