Restriction of Rift Valley Fever Virus Virulence in Mosquito Cells

Viruses

Valerie M. Vaughn²  Cale C. Streeter³  David J. Miller¹ 

[1] Department of Microbiology and Immunology, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA; E-Mail: [e-mail] (D.J.M.);Medical Scientist Training Program, School of Medicine, University of Michigan, Ann Arbor, Michigan, USA; E-Mail: [e-mail] (V.M.V.);Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA; E-Mail: [e-mail] (C.C.S.)

关键词: arbovirus;    arthropod;    NSs;    non-structural protein;    innate immunity;    cytopathic effect;    virulence factor;   

DOI  :  10.3390/v2020655

来源: mdpi

【 摘 要 】

Arboviruses are maintained in a natural cycle that requires blood-sucking arthropod and vertebrate hosts. Arboviruses are believed to persistently infect their arthropod host without overt pathology and cause acute infection with viremia in their vertebrate host. We have focused on elucidating how a specific arbovirus, Rift Valley fever (RVF) virus, causes cytopathic effect in cells derived from vertebrates and non-cytopathic infection in cells derived from arthropods. We demonstrate that the vertebrate virulence factor, NSs, is functional in arthropod cells but is expressed at significantly lower levels in infected arthropod versus infected vertebrate cells.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland