Development of Anodic Titania Nanotubes for Application in High Sensitivity Amperometric Glucose and Uric Acid Biosensors

Sensors

Hsiang-Ching Lee²  Li-Fan Zhang¹  Jyh-Ling Lin¹  Yuan-Lung Chin¹ 

[1] Department of Electronic Engineering, Huafan University, Shihding, Taipei Hsien 223-01, Taiwan; E-Mails:;Department of Mechatronic Engineering, Huafan University, Shihding, Taipei Hsien 223-01, Taiwan; E-Mail:

关键词: titania nanotubes (TNTs);    amperometry;    glucose;    uric acid (UA);   

DOI  :  10.3390/s131014161

来源: mdpi

【 摘 要 】

The purpose of this study was to develop novel nanoscale biosensors using titania nanotubes (TNTs) made by anodization. Titania nanotubes were produced on pure titanium sheets by anodization at room temperature. In this research, the electrolyte composition ethylene glycol 250 mL/NH₄F 1.5 g/DI water 20 mL was found to produce the best titania nanotubes array films for application in amperometric biosensors. The amperometric results exhibit an excellent linearity for uric acid (UA) concentrations in the range between 2 and 14 mg/dL, with 23.3 (μA·cm⁻²)·(mg/dL)⁻¹ UA sensitivity, and a correlation coefficient of 0.993. The glucose biosensor presented a good linear relationship in the lower glucose concentration range between 50 and 125 mg/dL, and the corresponding sensitivity was approximately 249.6 (μA·cm⁻²)·(100 mg/dL)⁻¹ glucose, with a correlation coefficient of 0.973.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.