Associations of Job Stress Indicators with Oxidative Biomarkers in Japanese Men and Women

International Journal of Environmental Research and Public Health

关键词: biomarkers;    demands-control-support model;    effort-reward imbalance model;    oxidative stress;    occupational health;    psychological stress;    sex factors;   

DOI  :  10.3390/ijerph10126662

来源: mdpi

【 摘 要 】

Some researchers have suggested that oxidative damage may be one of the mechanisms linking job stress with coronary heart disease. The aim of this study was to investigate the association between job stress indicators and oxidative biomarkers. The study included 567 subjects (272 men, 295 women) who answered questionnaires related to their work and underwent a medical examination. Job stress evaluated using the demands-control-support model was measured using the Job Content Questionnaire. Effort-reward imbalance was measured using the Effort-Reward Imbalance Questionnaire. Urinary hydrogen peroxide (H₂O₂) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured by the modified ferrous ion oxidation xylenol orange version-1 method and enzyme-linked immunosorbent assay, respectively. In men, the changes in the odds ratios for high urinary H₂O₂ associated with a 1-standard-deviation (SD) increase in worksite social support were 0.69 (95% confidence interval (CI) 0.53, 0.91) univariately and 0.68 (95%CI 0.51, 0.90) after adjustment for covariates. The change in the odds ratio for high urinary H₂O₂ associated with a 1-SD increase in effort-reward ratio was 1.35 (95% CI 1.03, 1.78) after adjustment for covariates. In women, there were no significant associations of the two job stress indicators with urinary H₂O₂ and 8-OHdG levels after adjustment for covariates (p > 0.05).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.