Pro-Apoptotic Effect of Rice Bran Inositol Hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells

International Journal of Molecular Sciences

Nurul Husna Shafie¹  Norhaizan Mohd Esa¹  Hairuszah Ithnin²  Norazalina Saad² 

[1] Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia; E-Mail:;UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia; E-Mails:

关键词: inositol hexaphosphate;    rice bran;    apoptosis;    colorectal cancer;   

DOI  :  10.3390/ijms141223545

来源: mdpi

【 摘 要 】

Inositol hexaphosphate (IP₆), or phytic acid is a natural dietary ingredient and has been described as a “natural cancer fighter”, being an essential component of nutritional diets. The marked anti-cancer effect of IP₆ has resulted in our quest for an understanding of its mechanism of action. In particular, our data provided strong evidence for the induction of apoptotic cell death, which may be attributable to the up-regulation of Bax and down-regulation of Bcl-xl in favor of apoptosis. In addition, the up-regulation of caspase-3 and -8 expression and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells when exposed to IP₆. Collectively, this present study has shown that rice bran IP₆ induces apoptosis, by regulating the pro- and anti-apoptotic markers; Bax and Bcl-xl and via the activation of caspase molecules (caspase-3 and -8).

【 授权许可】

CC BY   
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