International Journal of Molecular Sciences | |
The Involvement of miR-23a/ |
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Fung Lin Yong1  Chee Woon Wang2  April Camilla Roslani1  | |
[1] Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mails:;Department of Biochemistry, Faculty of Medicine, MAHSA University, Kuala Lumpur 59100, Malaysia; E-Mail: | |
关键词: miR-23a; APAF1; colorectal cancer; apoptosis; SW480; SW620; | |
DOI : 10.3390/ijms150711713 | |
来源: mdpi | |
【 摘 要 】
Recent advances in microRNAome have made microRNAs (miRNAs) a compelling novel class of biomarker in cancer biology. In the present study, the role of miR-23a in the carcinogenesis of colorectal cancer (CRC) was investigated. Cell viability, apoptosis, and caspase 3/7 activation analyses were conducted to determine the potentiality of apoptosis resistance function of miR-23a in CRC. Luciferase assay was performed to verify a putative target site of miR-23a in the 3'-UTR of apoptosis protease activating factor 1 (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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