Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial

Nutrients

卷:13

RaymondS. Y. Tang¹  JustinC. Y. Wu¹  StephenK. W. Tsui²  KamLeung Chan³  JessicaY. L. Ching³  BernardM. H. Law⁴  KaiChow Choi⁴  JudyY. W. Chan⁴  WinnieK. W. So⁴  CarmenW. H. Chan⁴ 

[1] Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China;

[2] School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China;

[3] School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China;

[4] The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China;

关键词: rice bran;    dietary intervention;    intestinal microbiota;    intestinal health;    colorectal cancer;   

DOI  :  10.3390/nu13020526

来源: DOAJ

【 摘 要 】

Rice bran exhibits chemopreventive properties that may help to prevent colorectal cancer (CRC), and a short-term rice bran dietary intervention may promote intestinal health via modification of the intestinal microbiota. We conducted a pilot, double-blind, randomised placebo-controlled trial to assess the feasibility of implementing a long-term (24-week) rice bran dietary intervention in Chinese subjects with a high risk of CRC, and to examine its effects on the composition of their intestinal microbiota. Forty subjects were randomised into the intervention group (n = 19) or the control group (n = 20). The intervention participants consumed 30 g of rice bran over 24-h intervals for 24 weeks, whilst the control participants consumed 30 g of rice powder on the same schedule. High rates of retention (97.5%) and compliance (≥91.3%) were observed. No adverse effects were reported. The intervention significantly enhanced the intestinal abundance of Firmicutes and Lactobacillus, and tended to increase the Firmicutes/Bacteroidetes ratio and the intestinal abundance of Prevotella_9 and the health-promoting Lactobacillales and Bifidobacteria, but had no effect on bacterial diversity. Overall, a 24-week rice bran dietary intervention was feasible, and may increase intestinal health by inducing health-promoting modification of the intestinal microbiota. Further larger-scale studies involving a longer intervention duration and multiple follow-up outcome assessments are recommended.

【 授权许可】

Unknown