The Phenolics from the Roots of Livistona chinensis Show Antioxidative and Obsteoblast Differentiation Promoting Activity

Molecules

Xiaobin Zeng²  Jun Tian³  Liao Cui²  Yang Wang¹  Yanjie Su²  Xin Zhou² 

[1] Shenzhen Xinpeng Shengwu Gongcheng Co. LTD, Shenzhen 518055, Guangdong, China; E-Mail:;Guangdong Key Laboratory for Research and Development of Natural Drugs, Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, Guangdong, China; E-Mails:;College of Life Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, China; E-Mail:

关键词: phenolic;    flavane;    Livistona chinensis;    osteoporosis;    oxidative stress;   

DOI  :  10.3390/molecules19010263

来源: mdpi

【 摘 要 】

This study investigated the antioxidative and obsteoblast differentiation promoting activity of the phenolics isolated from the 70% ethanol extract of the roots of Livistona chinensis. Two new phenolics, (2R,3R)-3,5,6,7,3',4'-hexahydroxyflavane (1), and phenanthrene-2,4,9-triol (2), together with six known phenolics 3–8, were isolated and identified on the basis of extensive spectroscopic analysis. The antioxidative and obsteoblast differentiation promoting abilities of the compounds 1–3, 7–8 were tested, the phenolics 1–3, 7 showed effects on proliferation of osteoblastic cells and antioxidative activity of 3.125–50 µg/mL. In addition, the phenolics 1–3 observably increased alkaline phosphatase activity, osteocalcin content and hydroxyproline content in osteoblastic cells. Phenolic 1 at 12.5 µg/mL concentration significantly increased the area of nodules by about 9.35-fold. The antioxidative activity results indicated that the anti-osteoporosis effects of these phenolics may be linked to a reduction of oxidative stress. The observed effects of these phenolics on bone formation by rat osteoblastic cells suggest that these phenolics may have beneficial effects on bone health.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.