Targeting Nuclear Receptors with Marine Natural Products

Marine Drugs

Chunyan Yang¹  Qianrong Li² 

[1] State Key Laboratory of Cellular Stress Biology, Innovation Center of Cell Biology Research, School of Life Sciences, Xiamen University, Xiamen 361102, China; E-Mail

关键词: nuclear receptors;    marine natural products;    ligands;    screen;    drug targets;   

DOI  :  10.3390/md12020601

来源: mdpi

【 摘 要 】

Nuclear receptors (NRs) are important pharmaceutical targets because they are key regulators of many metabolic and inflammatory diseases, including diabetes, dyslipidemia, cirrhosis, and fibrosis. As ligands play a pivotal role in modulating nuclear receptor activity, the discovery of novel ligands for nuclear receptors represents an interesting and promising therapeutic approach. The search for novel NR agonists and antagonists with enhanced selectivities prompted the exploration of the extraordinary chemical diversity associated with natural products. Recent studies involving nuclear receptors have disclosed a number of natural products as nuclear receptor ligands, serving to re-emphasize the translational possibilities of natural products in drug discovery. In this review, the natural ligands of nuclear receptors will be described with an emphasis on their mechanisms of action and their therapeutic potentials, as well as on strategies to determine potential marine natural products as nuclear receptor modulators.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.