Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

Molecules

Zhi-Gang Cheng⁴  Xu-Yong Dai³  Li-Wei Li¹  Qiong Wan²  Xiang Ma⁴ 

[1] College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, Hubei, China; E-Mail:;Hubei Biocause Heilen Pharmaceutical Co., Ltd, Jingmen 448000, Hubei, China; E-Mail:;Wuhan Biocause Pharmaceutical Development Co., Ltd, Wuhan 430056, Hubei, China; E-Mail:;School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; E-Mail:

关键词: barnidipine hydrochloride;    impurities;    antihypertensive agent;   

DOI  :  10.3390/molecules19011344

来源: mdpi

【 摘 要 】

Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, ¹H-NMR, and ¹³C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.