Marine Natural Products with P-Glycoprotein Inhibitor Properties

Marine Drugs

Dioxelis Lopez¹ 

[1] Center for Drug Discovery and Biodiversity, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, P.O. Box 0843-01103, Panama; E-Mail:

关键词: P-glycoprotein;    marine natural products;    multidrug resistance;   

DOI  :  10.3390/md12010525

来源: mdpi

【 摘 要 】

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.