Characterization and Antioxidant Properties of Six Algerian Propolis Extracts: Ethyl Acetate Extracts Inhibit Myeloperoxidase Activity

International Journal of Molecular Sciences

Yasmina Mokhtaria Boufadi¹  Jalal Soubhye²  Ali Riazi¹  Alexandre Rousseau³  Michel Vanhaeverbeek³  Jean Nève²  Karim Zouaoui Boudjeltia³ 

[1] Laboratory of Beneficial Microorganisms, Functional Food and Health (LMBAFS), Faculty of Natural Sciences and Life, University of Abdelhamid Ibn Badis, Mostaganem 27000, Algeria; E-Mails:;Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universite Libre de Bruxelles, Brussels 1050, Belgium; E-Mails:;Laboratory of Experimental Medicine, CHU Charleroi, A. Vésale Hospital, Universite Libre de Bruxelles, Montigny-le-Tilleul 6110, Belgium; E-Mails:

关键词: propolis;    oxidative stress;    free radical scavenging;    myeloperoxidase inhibition;    LDL oxidation inhibition;   

DOI  :  10.3390/ijms15022327

来源: mdpi

【 摘 要 】

Because propolis contains many types of antioxidant compounds such as polyphenols and flavonoids, it can be useful in preventing oxidative damages. Ethyl acetate extracts of propolis from several Algerian regions show high activity by scavenging free radicals, preventing lipid peroxidation and inhibiting myeloperoxidase (MPO). By fractioning and assaying ethyl acetate extracts, it was observed that both polyphenols and flavonoids contribute to these activities. A correlation was observed between the polyphenol content and the MPO inhibition. However, it seems that kaempferol, a flavonoid, contributes mainly to the MPO inhibition. This molecule is in a high amount in the ethyl acetate extract and demonstrates the best efficiency towards the enzyme with an inhibiting concentration at 50% of 4 ± 2 μM.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland