Effects of Propolis on Serum Biochemical Parameters in Azaserine Treated Rats

Natural and Engineering Sciences

article

Hasan Yıldız¹  Ümit Miçooğulları² 

[1] Hatay Mustafa Kemal University, Faculty of Arts and Sciences, Department of Biology;Hatay Mustafa Kemal University, Institute of Science and Technology, Department of Biology

关键词: Azaserine;    propolis;    serum;    oxidative stress;   

DOI  :  10.28978/nesciences.1142700

学科分类：数学（综合）

来源: Natural and Engineering Sciences

【 摘 要 】

Azaserine (o-diazoacetyl-L-serine) is an antimetabolite obtained from streptomycetes cultures and is used experimentally to produce atypical acinar cell focus (AACF) in rat exocrine pancreas. Propolis is a resinous hive product with antioxidant, anticarcinogenic, antimicrobial and anti-inflammatory effects that bees collect from the plants around them. In this study, we aimed performed to investigate the effect of ethanol extract of propolis (EEP) on serum biochemical changes in azaserin induced pancreatic cancer in Wistar rats. For this purpose, male Wistar albino rats were randomly divided into 4 groups, 10 in each group. AzCt and AzProp group 2-week-old male rats were given azaserine (30 mg/kg bw) intraperitoneally (ip). Propolis (EEP) (oral 80 mg/lt) was added to the drinking water of Prop and AzProp group rats. For the first time in this study, the effects of propolis on rats with neoplastic structures formed by azaserine were investigated in terms of biochemical parameters (AST, ALP, ALT, BILD, BILT, CHOL, LDH, TRIG, UREA, TAS, TOS and OSI). According to this; AzProp group values were compared to AzCt group, respectively, AST, UREA, TOS and OSI, there is a statistically significant difference in terms of values. As a result, it was seen that the oxidative stress caused by azaserine-induced neoplastic structures decreased with the use of propolis and that propolis had a positive effect on the measured biochemical parameters.

【 授权许可】

CC BY