Antimicrobial Plant Extracts Encapsulated into Polymeric Beads for Potential Application on the Skin

Polymers

Patrໜia Rijo¹  Diogo Matias¹  Ana S. Fernandes¹  M. Fátima Simཞs²  Marisa Nicolai¹ 

[1] CBiOS—Center for Research in Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, Lisboa 1749-024, Portugal; E-Mails:;Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa 1649-003, Portugal; E-Mail:

关键词: Plectranthus;    antimicrobial activity;    antioxidant activity;    polymeric beads;    alginate;    extraction methods;   

DOI  :  10.3390/polym6020479

来源: mdpi

【 摘 要 】

In this study, the in vitro bacterial growth inhibition, antioxidant activity and the content in bioactive components of Plectranthus barbatus, P. hadiensis var. tomentosus, P. madagascarensis, P. neochilus and P. verticillatus aqueous extracts were investigated and compared by three extraction methods (infusion, decoction and microwave extractions). The microwave extract of P. madagascariensis showed the higher antimicrobial activity against the Staphylococcus epidermidis strain with a minimum inhibitory concentration of 40 µg/mL. This extract also showed no toxicity in a general toxicity assay and no considerable cytotoxicity against a human keratinocyte cell line. The antioxidant activity of the extracts was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH method), and all showed antioxidant activity. The microwave extract of P. madagascariensis was the one with the highest antioxidant activity (IC₅₀ value of 41.66 µg/mL). To increase extract stability, the microwave P. madagascariensis extract was then successfully encapsulated into alginate beads with high efficiency. This effective and low-cost strategy seems to be easy to extrapolate to an industrial scale with a future application on the skin.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.