Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities

Química Nova

Sarmiento-Sánchez, Juan I.¹  Autonomous University of Sinaloa, Culiacán, México¹  Bastidas-Bastidas, Pedro¹  Instituto Tecnológico de Tijuana, Tijuana, México¹  Wilson-Corral, Victor¹  Delgado-Vargas, Francisco¹  Díaz-Camacho, Sylvia P.¹  Centro de Investigación en Alimentación y Desarrollo, México¹  Montes-Avila, Julio¹  García-Páez, Fernando¹  Ochoa-Terán, Adrián¹ 

关键词: 1H-benzoxazine-2;    4-dione;    antimicrobial activity;    antioxidant activity;    toxicity.;   

DOI  :  10.5935/0100-4042.20140201

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino[2,3-][1,3]oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).

【 授权许可】

Unknown