Microwave-assisted synthesis of benzoxazinediones under solvent-free conditions

Green Chemistry Letters and Reviews

Juan I. Sarmiento-Sánchez¹ 

关键词: 1H-benzoxazine-2;    4-dione;    microwave synthesis;    solvent-free;    green chemistry;   

DOI  :  10.1080/17518253.2016.1230654

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

Benzoxazinediones exhibit potential as versatile synthons in the synthesis of wide variety of heterocyclic compounds with biological activity. In this work, an efficient and eco-friendly one-step synthesis of benzoxazine-2,4-diones from phthalic anhydrides derivatives and trimethylsilyl azide using the microwave technique was developed and compared with conventional heating. Microwave irradiation plays a critical role in driving the reaction and providing access to products and/or regioisomers not available from conventional heating. Thus, the regioselectivity of the reaction may be modulated by the irradiation time. Depending on the method employed the benzoxazinediones were isolated with yields in the range of 30–90%.

【 授权许可】

Unknown