Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities

Química Nova

Juan I. Sarmiento-sánchez²  Julio Montes-avila¹  Adrián Ochoa-terán¹  Francisco Delgado-vargas¹  Victor Wilson-corral²  Sylvia P. Díaz-camacho¹  Fernando García-páez²  Pedro Bastidas-bastidas¹ 

[1] ,Autonomous University of Sinaloa Faculty of Engineering Culiacán Sinaloa ,México

关键词: 1H-benzoxazine-2;    4-dione;    antimicrobial activity;    antioxidant activity;    toxicity;   

DOI  :  10.5935/0100-4042.20140201

来源: SciELO

【 摘 要 】

A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino[2,3-][1,3]oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).

【 授权许可】

CC BY-NC   
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