期刊论文详细信息
Química Nova
Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities
Juan I. Sarmiento-sánchez2  Julio Montes-avila1  Adrián Ochoa-terán1  Francisco Delgado-vargas1  Victor Wilson-corral2  Sylvia P. Díaz-camacho1  Fernando García-páez2  Pedro Bastidas-bastidas1 
[1] ,Autonomous University of Sinaloa Faculty of Engineering Culiacán Sinaloa ,México
关键词: 1H-benzoxazine-2;    4-dione;    antimicrobial activity;    antioxidant activity;    toxicity;   
DOI  :  10.5935/0100-4042.20140201
来源: SciELO
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【 摘 要 】

A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino[2,3-][1,3]oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License

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