Nanomaterials | |
Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response | |
Yukari Totsuka2  Kousuke Ishino2  Tatsuya Kato2  Sumio Goto4  Yukie Tada1  Dai Nakae1  Masatoshi Watanabe3  | |
[1] Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health, 3-24-1 Hyakunin-cho, Shinjuku-ku, Tokyo 169-0073, Japan; E-Mails:;Division of Cancer Development System, National Cancer Center Research Institute, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan; E-Mails:;Division of Materials Science and Engineering, Graduate School of Engineering, Yokohama National University, Hodogaya-ku, Yokohama 240-8501, Japan; E-Mail:;Laboratory of Environmental Risk Evaluation, School of Life and Environmental Science, Azabu University, 1-17-71 Fuchinobe, Chuou-ku, Sagamihara, Kanagawa 252-5201, Japan; E-Mail: | |
关键词: magnetite nanoparticle (MGT); pulmonary inflammation; intratracheal instillation; DNA damage; genotoxicity; | |
DOI : 10.3390/nano4010175 | |
来源: mdpi | |
【 摘 要 】
Nanomaterials are useful for their characteristic properties and are commonly used in various fields. Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields, whereas their toxicological properties are not well documented. A safety assessment is thus urgently required for MGT, and genotoxicity is one of the most serious concerns. In the present study, we examined genotoxic effects of MGT using mice and revealed that DNA damage analyzed by a comet assay in the lungs of imprinting control region (ICR) mice intratracheally instilled with a single dose of 0.05 or 0.2 mg/animal of MGT was approximately two- to three-fold higher than that of vehicle-control animals. Furthermore, in
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190028126ZK.pdf | 551KB | download |