Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

International Journal of Molecular Sciences

Li Zhang¹  Zhijie He¹  Qi Zhang¹  Yi Wu¹  Xiaojiao Yang¹  Wenxiu Niu¹  Yongshan Hu¹ 

[1] Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China; E-Mails:

关键词: exercise pretreatment;    mitochondrial dynamics;    OPA1;    cerebral ischemia;    neuroprotection;   

DOI  :  10.3390/ijms15034453

来源: mdpi

【 摘 要 】

Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland