In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

Nutrients

Suk-Nam Kang⁴  Jong Seok Lee⁶  Joung-Hyun Park²  Jae-Hyeon Cho³  Jae-Hong Park⁵  Kwang-Keun Cho¹  Ok-Hwan Lee⁶ 

[1] Department of Animal Resource Technology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea; E-Mail:;Department of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 608-737, Korea; E-Mail:;Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea; E-Mail:;Department of Animal Resources, Daegu University, Gyeongsan 712-714, Korea; E-Mail:;Department of Animal Resource and Science, Dankook University, Choongnam 330-714, Korea; E-Mail:;Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea; E-Mail:

关键词: Drynariae rhizoma;    extraction solvent;    phenolic compounds;    antioxidant;    anti-osteoporosis;   

DOI  :  10.3390/nu6041737

来源: mdpi

【 摘 要 】

Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (−)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.