Molecules | |
Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats | |
Xinchi Feng1  Youping Liu1  Xin Wang1  | |
[1] School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China; | |
关键词: linarin; piperine; P-glycoprotein; intestinal permeability; pharmacokinetics; | |
DOI : 10.3390/molecules19055624 | |
来源: mdpi | |
【 摘 要 】
Although linarin possesses diverse pharmacological activities, its poor oral bioavailability has been a concern for further development. The present study aimed to demonstrate the feasibility of improving the oral absorption of linarin in rats with a bioenhancer‒piperine. First, the intestinal permeability of linarin in the presence and absence of verapamil or piperine was investigated using an
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190026452ZK.pdf | 499KB | download |