The influence of piperine on the bioavailability of drugs: a molecular approach

Química Nova

Universidade Federal do Vale do São Francisco, Petrolina, Brasil¹  Alencar - Filho, Edilson B.¹  Universidade Federal da Paraíba, João Pessoa, Brasil¹  Vasconcellos, Mário L. A. A.¹  Oliveira, Ramon G. de¹ 

关键词: piperine;    enzymatic inhibition;    molecular docking.;   

DOI  :  10.1590/S0100-40422014000100013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Piperine is the major alkaloid of Piper nigrum Linn., used as a spice and in folk medicine. We present a molecular docking study supporting experimental data on the enhancement in bioavailability of propranolol, theophylline, phenytoin, nevirapine, nimesulide, pyrazinamide, carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with a binding energy of -8.60 kcal/mol. This explains the related mechanism of drug-herb interaction, since the better anchoring of piperine in the active site of CYP3A4 can hinder the drug-enzyme interaction, thereby increasing the bioavailability of the drugs studied.

【 授权许可】

Unknown