The influence of piperine on the bioavailability of drugs: a molecular approach

Quimica nova

Vasconcellos, Mário L. A. A.¹  Oliveira, Ramon G. de¹  Alencar - Filho, Edilson B.² 

[1] Universidade Federal da Paraíba, João Pessoa, Brasil;Universidade Federal do Vale do São Francisco, Petrolina, Brasil

关键词: piperine;    enzymatic inhibition;    molecular docking.;   

DOI  :  10.1590/S0100-40422014000100013

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Piperine is themajor alkaloid of Piper nigrum Linn., used as a spice and in folk medicine.We present a molecular docking study supporting experimental data on the enhancementin bioavailability of propranolol, theophylline, phenytoin, nevirapine, nimesulide,pyrazinamide, carbamazepine, and spartein in the presence of piperine. The complexformed with piperine and CYP3A4 was shown to be the most stable of all, witha binding energy of -8.60 kcal/mol. This explains the related mechanism of drug-herbinteraction, since the better anchoring of piperine in the active site of CYP3A4can hinder the drug-enzyme interaction, thereby increasing the bioavailabilityof the drugs studied.

【 授权许可】

CC BY