Effect of Long-Term Dietary Arginyl-Fructose (AF) on Hyperglycemia and HbA1c in Diabetic db/db Mice

International Journal of Molecular Sciences

Kwang-Hyoung Lee³  Kyoung-Soo Ha¹  Sung-Hoon Jo¹  Chong M. Lee⁴  Young-Cheul Kim²  Kwang-Hoe Chung³ 

[1] Department of Food and Nutrition, Hannam University, Daejeon 305-811, Korea; E-Mails:;Department of Nutrition, University of Massachusetts, Amherst, MA 01003, USA; E-Mail:;Thrombosis and Vascular Biochemistry Lab., Department of Applied Science, CHA University, Gyeonggi-do 463-836, Korea; E-Mail:;Department of Nutrition and Food Science, University of Rhode Island, Kingston, RI 02881, USA; E-Mail:

关键词: type 2 diabetes;    pre-diabetes;    blood glucose;    α-glucosidase inhibition;    arginyl-fructose (AF);   

DOI  :  10.3390/ijms15058352

来源: mdpi

【 摘 要 】

We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes. The db/db mice were randomly assigned to high-carbohydrate diets (66.1% corn starch) with and without AF (4% in the diet) for 6 weeks. Changes in body weight, blood glucose level, and food intake were measured daily for 42 days. Dietary supplementation of AF resulted in a significant decrease of blood glucose level (p < 0.001) and body weight (p < 0.001). The level of HbA1c, a better indicator of plasma glucose concentration over prolonged periods of time, was also significantly decreased for 6-week period (p < 0.001). Dietary treatment of acarbose^® (0.04% in diet), a positive control, also significantly alleviated the level of blood glucose, HbA1c, and body weight. These results indicate that AF Maillard reaction product improves postprandial hyperglycemia by suppressing glucose absorption as well as decreasing HbA1c level.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland