HIV DNA Vaccine: Stepwise Improvements Make a Difference

Vaccines

Barbara K. Felber¹  Antonio Valentin²  Margherita Rosati²  Cristina Bergamaschi¹ 

[1] Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA; E-Mail:;Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA; E-Mails:

关键词: macaque;    cytokine;    plasmid;    electroporation;    immunogenicity;    vaccination;    DNA delivery;    DNA expression;   

DOI  :  10.3390/vaccines2020354

来源: mdpi

【 摘 要 】

Inefficient DNA delivery methods and low expression of plasmid DNA have been major obstacles for the use of plasmid DNA as vaccine for HIV/AIDS. This review describes successful efforts to improve DNA vaccine methodology over the past ~30 years. DNA vaccination, either alone or in combination with other methods, has the potential to be a rapid, safe, and effective vaccine platform against AIDS. Recent clinical trials suggest the feasibility of its translation to the clinic.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.