Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells

Nutrients

Andrew Pipingas²  Robyn Cockerell²  Natalie Grima³  Andrew Sinclair¹  Con Stough²  Andrew Scholey²  Stephen Myers⁶  Kevin Croft⁴  Avni Sali⁵ 

[1] Metabolic Research Unit, School of Medicine, Deakin University, Melbourne 3216, Australia; E-Mail:;Centre for Human Psychopharmacology, Swinburne University of Technology, P.O. Box 218, Hawthorn 3122, Australia; E-Mails:;Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton VIC 3800, Australia; E-Mail:;School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia; E-Mail:;National Institute of Integrative Medicine, Hawthorn 3122, Australia; E-Mail:;NatMed-Research Unit, Southern Cross University, Lismore NSW 2480, Australia; E-Mail:

关键词: fish oils;    multivitamins;    n-3;    randomized;    controlled trial (RCT);    fatty acid;    diet;   

DOI  :  10.3390/nu6051956

来源: mdpi

【 摘 要 】

The present randomized, placebo-controlled, double-blind, parallel-groups clinical trial examined the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells. Healthy adult humans (n = 160) were randomized to receive 6 g of fish oil, 6 g of fish oil plus a multivitamin, 3 g of fish oil plus a multivitamin or a placebo daily for 16 weeks. Treatment with 6 g of fish oil, with or without a daily multivitamin, led to higher eicosapentaenoic acid (EPA) composition at endpoint. Docosahexaenoic acid (DHA) composition was unchanged following treatment. The long chain LC n-3 PUFA index was only higher, compared to placebo, in the group receiving the combination of 6 g of fish oil and the multivitamin. Analysis by gender revealed that all treatments increased EPA incorporation in females while, in males, EPA was only significantly increased by the 6 g fish oil multivitamin combination. There was considerable individual variability in the red blood cell incorporation of EPA and DHA at endpoint. Gender contributed to a large proportion of this variability with females generally showing higher LC n-3 PUFA composition at endpoint. In conclusion, the incorporation of LC n-3 PUFA into red blood cells was influenced by dosage, the concurrent intake of vitamin/minerals and gender.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.