期刊论文详细信息
Marine Drugs
The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy
Jing Wang1  Huaide Liu2  Ning Li1  Quanbin Zhang1 
[1] Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; E-Mails:;School of Life Sciences, Nantong University, Seyuan Road 9, Nantong 226019, China; E-Mail:
关键词: sulfated polysaccharide;    fucoidan;    diabetic nephropathy;   
DOI  :  10.3390/md12063292
来源: mdpi
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【 摘 要 】

Diabetic nephropathy (DN) has long been recognized as the leading cause of end-stage renal disease, but the efficacy of available strategies for the prevention of DN remains poor. The aim of this study was to investigate the possible beneficial effects of fucoidan (FPS) in streptozotocin (STZ)-induced diabetes in rats. Wistar rats were made diabetic by injection of STZ after removal of the right kidney. FPS was administered to these diabetic rats for 10 weeks. Body weight, physical activity, renal function, and renal morphometry were measured after 10 weeks of treatment. In the FPS-treated group, the levels of blood glucose, BUN, Ccr and Ucr decreased significantly, and microalbumin, serum insulin and the β2-MG content increased significantly. Moreover, the FPS-treated group showed improvements in renal morphometry. In summary, FPS can ameliorate the metabolic abnormalities of diabetic rats and delay the progression of diabetic renal complications.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

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