Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schröederi in Wistar rats

Revista Brasileira de Farmacognosia

Almeida-Lima, Jailma¹  Silva, Naisandra B.¹  Cordeiro, Sara L.¹  Freitas, Maria de L.¹  Gomes, Dayanne L.¹  Moura, Carlos E. B.¹  Universidade Federal do Rio Grande do Norte, Brazil¹  Dantas-Santos, Nednaldo¹  Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Norte, Brazil¹  Lemos, Telma M. A. M.¹  Leite, Edda L.¹  Sabry, Diego A.¹  Rocha, Hugo A. O.¹  Costa, Leandro S.¹ 

关键词: brown seaweed;    fucoidan;    sulfated polysaccharide;    toxicological assessment;   

DOI  :  10.1590/S0102-695X2011005000098

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

: Fucan is a term used to denominate a family of sulfated polysaccharides rich in L-fucose. The brown alga Spatoglossum schröederi, Dictyotaceae, synthesizes three heterofucans named A, B, and C. Fucan A is a non-anticoagulant heterofucan which possesses potent antithrombotic (in vivo) and antiproliferative (in vitro) activities. However, its toxicity in vivo has not been determined. The present study examined the acute and subchronic toxicity of the fucan A in Wistar rats after subcutaneous administration. After that, the animals were killed and examined. The results showed in the acute study that fucan A did not cause general adverse effects and mortality in the concentrations 0, 20, 100, 1000, and 2000 µg/g body weight per rat for seven days. Regarding the subchronic study, the data showed that the fucan A did not cause any change in hematological and biochemistry parameters, as well as in the morphology, and in the size of the rat's organs analyzed at a concentration of 20 µg/g body weight per rat during a 62-day period. In conclusion, this study indicates this heterofucan is a compound with potential pharmacological value that has no toxicity in vivo.

【 授权许可】

Unknown