期刊论文详细信息
Vaccines
Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus
Elissa J. Schwartz1 
[1] School of Biological Sciences, Department of Mathematics, Washington State University, Pullman, WA 99164, USA; E-Mail:
关键词: equine infectious anemia virus;    vaccination;    antibodies;    mathematical modeling;    lentivirus;   
DOI  :  10.3390/vaccines2020397
来源: mdpi
PDF
【 摘 要 】

The ability to predict the conditions under which antibodies protect against viral infection would transform our approach to vaccine development. A more complete understanding is needed of antibody protection against lentivirus infection, as well as the role of mutation in resistance to an antibody vaccine. Recently, an example of antibody-mediated vaccine protection has been shown via passive transfer of neutralizing antibodies before equine infectious anemia virus (EIAV) infection of horses with severe combined immunodeficiency (SCID). Viral dynamic modeling of antibody protection from EIAV infection in SCID horses may lead to insights into the mechanisms of control of infection by antibody vaccination. In this work, such a model is constructed in conjunction with data from EIAV infection of SCID horses to gain insights into multiple strain competition in the presence of antibody control. Conditions are determined under which wild-type infection is eradicated with the antibody vaccine. In addition, a three-strain competition model is considered in which a second mutant strain may coexist with the first mutant strain. The conditions that permit viral escape by the mutant strains are determined, as are the effects of variation in the model parameters. This work extends the current understanding of competition and antibody control in lentiviral infection, which may provide insights into the development of vaccines that stimulate the immune system to control infection effectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.

【 预 览 】
附件列表
Files Size Format View
RO202003190025475ZK.pdf 1301KB PDF download
  文献评价指标  
  下载次数:13次 浏览次数:7次