Molecules | |
A Novel Phage-Library-Selected Peptide Inhibits Human TNF-α Binding to Its Receptors | |
Jlenia Brunetti1  Barbara Lelli1  Silvia Scali1  Chiara Falciani2  Luisa Bracci1  | |
[1] Department of Medical Biotechnologies, University of Siena, Via A. Moro 2, 53100 Siena, Italy; E-Mails:;SetLance srl, via Fiorentina 1, 53100 Siena, Italy; E-Mail: | |
关键词: TNF-α; anti-TNF-α peptide; branched peptides; phage display; solid-phase synthesis; competitive selection; surface plasmon resonance; | |
DOI : 10.3390/molecules19067255 | |
来源: mdpi | |
【 摘 要 】
We report the identification of a new human tumor necrosis factor-alpha (TNF-α) specific peptide selected by competitive panning of a phage library. Competitive elution of phages was obtained using the monoclonal antibody adalimumab, which neutralizes pro-inflammatory processes caused by over-production of TNF-α
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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