MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

Molecules

Alina Georgiana Anghel²  Alexandru Mihai Grumezescu⁴  Mariana Chirea³  Valentina Grumezescu⁴  Gabriel Socol¹  Florin Iordache⁵  Alexandra Elena Oprea⁴  Ion Anghel² 

[1] National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania; E-Mail:;ENT, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania; E-Mails:;Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain;Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania; E-Mails:;Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology “Nicolae Simionescu” (ICBP), Bucharest 050568, Romania; E-Mail:

关键词: magnetite nanoparticles;    drug delivery;    MAPLE;    laser processing;    essential oils;    natural products;   

DOI  :  10.3390/molecules19078981

来源: mdpi

【 摘 要 】

Cinnamomum verum-functionalized Fe₃O₄ nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe₃O₄@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.