Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast

Inorganics

Anastasiia A. Kozlova¹  Daniil N. Bratashov¹  Sergey V. German²  Vsevolod S. Atkin³  Yulia I. Svenskaya³  Maxwell A. Astle⁴  Victor V. Zyev⁵  Dmitry A. Gorin⁶ 

[1] Biomedical photoacoustics lab, Saratov State University, Saratov 410012, Russia;Laboratory of objects and spectroscopy of nanoobjects of molecular spectroscopy department, Institute of Spectroscopy of the Russian Academy of Sciences (ISAN), Troitsk 108840, Russia;Research and Educational Institute of Nanostructures and Biosystems, Saratov State University, Saratov 410012, Russia;School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK;Scientific Research Institute of Fundamental and Clinical Uronephrology, Saratov State Medical University, Saratov 410012, Russia;Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow 121205, Russia;

关键词: magnetically-guided drug delivery systems;    magnetite nanoparticles;    magnetic resonance imaging (mri), polymeric core–shells;    magnetic submicron core–shells;    drug delivery;   

DOI  :  10.3390/inorganics8020011

来源: DOAJ

【 摘 要 】

Magnetic contrast agents are widely used in magnetic resonance imaging in order to significantly change the signals from the regions of interest in comparison with the surrounding tissue. Despite a high variety of single-mode T₁ or T₂ contrast agents, there is a need for dual-mode contrast from the one agent. Here, we report on the synthesis of magnetic submicron carriers, containing Fe₃O₄ nanoparticles in their structure. We show the ability to control magnetic resonance contrast by changing not only the number of magnetite nanoparticles in one carrier or the concentration of magnetite in the suspension but also the structure of the core−shell itself. The obtained data open up the prospects for dual-mode T₁/T₂ magnetic contrast formation, as well as provides the basis for future investigations in this direction.

【 授权许可】

Unknown