Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors

Nanotheranostics

article

Yulia Svenskaya¹  Francesca Garello²  Ekaterina Lengert¹  Anastasiia Kozlova³  Roman Verkhovskii³  Valeria Bitonto²  Maria Rosaria Ruggiero²  Sergey German⁴  Dmitry Gorin⁵  Enzo Terreno² 

[1] Remote Controlled Systems for Theranostics laboratory, Research and Educational Institute of Nanostructures and Biosystems, Saratov State University;Molecular and Preclinical Imaging Centres, Department of Molecular Biotechnology and Health Sciences, University of Torino;Biomedical Photoacoustics Laboratory, Saratov State University;Laboratory of Optics and Spectroscopy of Nanoobjects, Institute of Spectroscopy of the RAS;Center of Photonics and Quantum Materials, Skolkovo Institute of Science and Technology

关键词: magnetically-guided drug delivery systems;    polyelectrolyte submicron capsules;    magnetite nanoparticles;    magnetic resonance imaging;    targeted drug delivery.;   

DOI  :  10.7150/ntno.59458

学科分类：大气科学

来源: Ivyspring International Publisher

【 摘 要 】

Rationale: The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells. To overcome these issues, various nano- and micro-carriers have been developed so far, but some of them are characterized by slow degradation time, thus hampering repeated drug administrations. The aim of this study was to pursue a selective delivery of magnetic biodegradable polyelectrolyte capsules in a mouse breast cancer model, using an external magnetic field.

【 授权许可】

CC BY-NC