Punctaporonins H–M: Caryophyllene-Type Sesquiterpenoids from the Sponge-Associated Fungus Hansfordia sinuosae

Marine Drugs

Zehong Wu³  Dong Liu³  Peter Proksch²  Peng Guo¹ 

[1] Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China;Institute für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1, Geb.26.23, 40225 Düsseldorf, Germany; E-Mail:;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China; E-Mails:

关键词: sponge-associated fungus;    Hansfordia sinuosae;    punctaporonins H–M;    structural elucidation;    lowering lipid accumulation;   

DOI  :  10.3390/md12073904

来源: mdpi

【 摘 要 】

Six new caryophyllene-based sesquiterpenoids named punctaporonins H–M (1–6), together with punctaporonin B (7) and humulane (8) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. Their structures were determined by the extensive HRESIMS and NMR spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of punctaporonins H–I (1–2). The isolated compounds were evaluated for antihyperlipidemic, cytotoxic and antimicrobial activities, and punctaporonin K (4) exhibited potent effects to reduce the triglycerides and total cholesterol in the intracellular levels.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.