Chemistry of the Nudibranch Aldisa andersoni: Structure and Biological Activity of Phorbazole Metabolites

Marine Drugs

Genoveffa Nuzzo¹  Maria Letizia Ciavatta¹  Robert Kiss²  Véronique Mathieu²  Helene Leclercqz²  Emiliano Manzo¹  Guido Villani¹  Ernesto Mollo¹  Florence Lefranc³  Lisette D’Souza⁴  Margherita Gavagnin¹ 

[1] CNR, Instituto di Chimica Biomolecolare, Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy;Laboratoire de Toxicologie, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Campus de la Plaine, Boulevard du Triomphe, 1050, Brussels, Belgium;Service de Neurochirurgie, Hôpital Erasme, ULB, Route de Lennik, 1070 Brussels, Belgium;CSIR—National Institute of Oceanography, 403 004 Dona Paula, Goa, India;

关键词: Aldisa andersoni;    nudibranch mollusc;    structural elucidation;    feeding-deterrence;    growth inhibitory assays;   

DOI  :  10.3390/md10081799

来源: mdpi

【 摘 要 】

The first chemical study of the Indo-Pacific dorid nudibranch Aldisa andersoni resulted in the isolation of five chlorinated phenyl-pyrrolyloxazoles belonging to the phorbazole series. Two new molecules, 9-chloro-phorbazole D and N1-methyl-phorbazole A, co-occurring with known phorbazoles A, B and D, have been characterized. Phorbazoles were found to be present mainly in the external part of the mollusc. The structures of the new compounds were determined by interpretation of spectroscopic data, mainly NMR and mass spectrometry and by comparison with the literature data. Evaluation of feeding-deterrence activity as well as in vitro growth inhibitory properties in human cancer cells was also carried out.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.