New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04

Marine Drugs

Li-Jian Ding¹  Bin-Bin Gu²  Wei-Hua Jiao²  Wei Yuan²  Ying-Xin Li³  Wei-Zhuo Tang²  Hao-Bing Yu²  Xiao-Jian Liao¹  Bing-Nan Han²  Zhi-Yong Li³  Shi-Hai Xu¹  Hou-Wen Lin² 

[1] College of Pharmacy, Jinan University, Guangzhou 510632, China; E-Mails:;Marine Drugs Research Center, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; E-Mails:;State Key Laboratory of Microbial Metabolism, Marine Biotechnology Laboratory, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; E-Mail:

关键词: Hypocrea koningii;    sponge-associated fungus;    furan derivatives;    cyclopentenone derivatives;    antibacterial;    antioxidant;   

DOI  :  10.3390/md13095579

来源: mdpi

【 摘 要 】

Two new furan derivatives, hypofurans A and B (1 and 2), and three new cyclopentenone derivatives, hypocrenones A–C (3–5), along with seven known compounds (6–12), were isolated from a marine fungus Hypocrea koningii PF04 associated with the sponge Phakellia fusca. Among them, compounds 10 and 11 were obtained for the first time as natural products. The planar structures of compounds 1–5 were elucidated by analysis of their spectroscopic data. Meanwhile, the absolute configuration of 1 was determined as 2R,3R by the comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. All the isolates were evaluated for their antibacterial and antioxidant activity. Compounds 1, 10, and 12 all showed modest antibacterial activity against Staphylococcus aureus ATCC25923 (MIC, 32 μg/mL). In addition, compounds 1, 10 and 11 exhibited moderate DPPH radical scavenging capacity with IC₅₀ values of 27.4, 16.8, and 61.7 µg/mL, respectively.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.