Batch and Continuous Flow Preparation of Hantzsch 1,4-Dihydropyridines under Microwave Heating and Simultaneous Real-time Monitoring by Raman Spectroscopy. An Exploratory Study

Molecules

Sylvain Christiaens¹  Xavier Vantyghem¹  Marilena Radoiu² 

[1] Laboratory of Organic Chemistry, University of Mons-UMONS, 23 Place du Parc, B-7000 Mons, Belgium; E-Mails:;SAIREM SAS, 12 porte du Grand Lyon, F-01702 Neyron, France; E-Mail:

关键词: 1;    4-DHPs;    flow chemistry;    Hantzsch pyridines;    microwave;    Raman spectroscopy;    real-time monitoring;   

DOI  :  10.3390/molecules19079986

来源: mdpi

【 摘 要 】

Dialkyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates have been prepared in a batch mode under conventional heating as well as under continuous flow conditions in the Miniflow 200SS, Sairem’s microwave-assisted batch and continuous flow equipment. Real-time monitoring of the reactions by Raman spectroscopy enabled to compare both heating modes and to determine (optimized) reaction times.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.