Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B

Catalysts

Pavol Lopatka¹  Peter Koóš¹  Tibor Gracza¹  Michal Gavenda¹  Martin Markovič¹ 

[1] Institute of Organic Chemistry, Catalysis and Petrochemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia;

关键词: Jaspine B;    flow chemistry;    palladium catalysis;    cyclisation;    carbonylation;   

DOI  :  10.3390/catal11121513

来源: DOAJ

【 摘 要 】

This work describes the total synthesis of jaspine B involving the highly diastereoselective Pd(II)-catalysed carbonylative cyclisation in the preparation of crucial intermediates. New conditions for this transformation were developed and involved the pBQ/LiCl as a reoxidation system and Fe(CO)₅ as an in situ source of stoichiometric amount of carbon monoxide (1.5 molar equivalent). In addition, we have demonstrated the use of a flow reactor adopting proposed conditions in the large-scale preparation of key lactones.

【 授权许可】

Unknown