Short-Term Traffic-Related Exposures and Biomarkers of Nitro-PAH Exposure and Oxidative DNA Damage

Toxics

Andreas M. Neophytou⁴  Jaime E. Hart⁴  Yan Chang¹  Junfeng Zhang²  Thomas J. Smith⁴  Eric Garshick³ 

[1] Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA; E-Mail:;Nicholas School of the Environment, and Duke Global Health Institute, Duke University, Durham, NC 27708, USA; E-Mail:Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, MA 02132, USA;;Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA; E-Mails:

关键词: traffic emissions;    nitro-PAHs;    biomarkers;    oxidative stress;   

DOI  :  10.3390/toxics2030377

来源: mdpi

【 摘 要 】

Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer and greater overall mortality. We investigated whether amino-polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected at the beginning and end of a work week from 82 male U.S. trucking industry workers. We used repeated-measures analysis to examine associations of total 1- and 2-aminonaphthalene (1 & 2-AN) and 1-aminopyrene (1-AP) urinary concentrations with microenvironment exposures to particulate matter (PM_2.5), elemental and organic carbon and between 1 & 2-AN and 1-AP with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). There was an association between work week mean PM_2.5 levels and post-shift 1 & 2-AN (141.8 pg/mL increase (95% CI: 53.3, 230.2) for each IQR increase (5.54 µg/m³) in PM_2.5), but no associations with other exposure measures. There was a statistically significant increase in 8-OHdG concentrations with 1 & 2-AN (2.38 µg/mg creatinine (95% CI: 0.19, 4.58) per 242.85 pg/mg creatinine increase in 1 & 2-AN) and suggestive associations with all other exposure measures. Our findings suggest associations between urinary amino-PAHs with vehicle exhaust-related PM_2.5, as well as with a biomarker of oxidative DNA damage.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.