An Optofluidic Lens Array Microchip for High Resolution Stereo Microscopy

Micromachines

Mayurachat Ning Gulari¹  Anurag Tripathi³  Mostafa Ghannad-Rezaie² 

[1] Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA; E-Mail:;Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; E-Mail:;Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; E-Mail:

关键词: ball lens;    microscope;    oil immersion lens;    microlens;    stereo microscope;    high resolution imaging;    add-on module;    optofluidics;    microfabrication;   

DOI  :  10.3390/mi5030607

来源: mdpi

【 摘 要 】

We report the development of an add-on, chip-based, optical module—termed the Microfluidic-based Oil-immersion Lenses (μOIL) chip—which transforms any stereo microscope into a high-resolution, large field of view imaging platform. The μOIL chip consists of an array of ball mini-lenses that are assembled onto a microfluidic silicon chip. The mini-lenses are made out of high refractive index material (sapphire) and they are half immersed in oil. Those two key features enable submicron resolution and a maximum numerical aperture of ~1.2. The μOIL chip is reusable and easy to operate as it can be placed directly on top of any biological sample. It improves the resolution of a stereo microscope by an order of magnitude without compromising the field of view; therefore, we believe it could become a versatile tool for use in various research studies and clinical applications.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.