Antioxidant Activity and Mechanisms of Action of Natural Compounds Isolated from Lichens: A Systematic Review

Molecules

Pollyanna A. S. White³  Rita C. M. Oliveira¹  Aldeidia P. Oliveira¹  Mairim R. Serafini⁴  Adriano A. S. Araújo⁵  Daniel P. Gelain⁶  Jose C. F. Moreira⁶  Jackson R. G. S. Almeida²  Jullyana S. S. Quintans³  Lucindo J. Quintans-Junior³ 

[1]Medicinal Plants Research Center, Federal University of Piauí, Teresina, Piauí 64049-550, Brazil

[2] E-Mail:

[3]Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Petrolina, Pernambuco 56304-205, Brazil

[4] E-Mail:

[5]Department of Physiology, Federal University of Sergipe, São Cristóvão, Sergipe 49100-000, Brazil

[6] E-Mails:

[7]Nucleus of Pharmacy, Federal University of Sergipe, Lagarto, Sergipe 49100-000, Brazil

[8] E-Mail:

[9]Department of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe 49100-000, Brazil

[10] E-Mail:

[11]Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul 90035-003, Brazil

[12] E-Mails:

关键词: lichens;    antioxidants;    antioxidant response elements;    DPPH;    cancer;    chronic disease;   

DOI  :  10.3390/molecules190914496

来源: mdpi

【 摘 要 】

Chronic diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases are characterized by an enhanced state of oxidative stress, which may result from the overproduction of reactive species and/or a decrease in antioxidant defenses. The search for new chemical entities with antioxidant profile is still thus an emerging field on ongoing interest. Due to the lack of reviews concerning the antioxidant activity of lichen-derived natural compounds, we performed a review of the antioxidant potential and mechanisms of action of natural compounds isolated from lichens. The search terms “lichens”, “antioxidants” and “antioxidant response elements” were used to retrieve articles in LILACS, PubMed and Web of Science published until February 2014. From a total of 319 articles surveyed, 32 met the established inclusion and exclusion criteria. It was observed that the most common isolated compound studied was usnic acid, cited in 14 out of the 32 articles. The most often described antioxidant assays for the study of in vitro antioxidant activity were mainly DPPH, LPO and SOD. The most suggested mechanisms of action were scavenging of reactive species, enzymatic activation and inhibition of iNOS. Thus, compounds isolated from lichens are possible candidates for the management of oxidative stress, and may be useful in the treatment of chronic diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.