International Journal of Environmental Research and Public Health | |
Combination Effects of (Tri)Azole Fungicides on Hormone Production and Xenobiotic Metabolism in a Human Placental Cell Line | |
Svenja Rieke1  Sophie Koehn1  Karen Hirsch-Ernst1  Rudolf Pfeil1  Carsten Kneuer1  | |
[1]Federal Institute for Risk Assessment (BfR), Max-Dohrn-Str 8-10, 10589 Berlin, Germany | |
关键词: mixture toxicity; endocrine disruption; placenta; triazoles; | |
DOI : 10.3390/ijerph110909660 | |
来源: mdpi | |
【 摘 要 】
Consumers are exposed to multiple residues of different pesticides via the diet. Therefore, EU legislation for pesticides requires the evaluation of single active substances as well as the consideration of combination effects. Hence the analysis of combined effects of substances in a broad dose range represents a key challenge to current experimental and regulatory toxicology. Here we report evidence for additive effects for (tri)azole fungicides, a widely used group of antifungal agents, in the human placental cell line Jeg-3. In addition to the triazoles cyproconazole, epoxiconazole, flusilazole and tebuconazole and the azole fungicide prochloraz also pesticides from other chemical classes assumed to act via different modes of action (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190021877ZK.pdf | 1034KB | download |