Novel Formulations for Antimicrobial Peptides

International Journal of Molecular Sciences

Ana Maria Carmona-Ribeiro¹  Letໜia Dias de Melo Carrasco² 

[1] Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil; E-Mail

关键词: bilayer disks or fragments;    liposomes;    nanoparticles;    biocompatible polymers;    peptide covalent modification;    biopolymers;   

DOI  :  10.3390/ijms151018040

来源: mdpi

【 摘 要 】

Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.