Rafts, Nanoparticles and Neural Disease

Nanomaterials

Vishal Gulati¹ 

[1] Ross University School of Medicine, Miami Beach Community Health Center, 11645 Biscayne Boulevard, North Miami, FL 33181, USA;

关键词: rafts;    nanoparticles;    nanomedicine;    neural disease;    epilepsy;    Parkinson’s disease;    Alzheimer’s disease;    liposomes;    solid lipid nanoparticles;   

DOI  :  10.3390/nano2030217

来源: mdpi

【 摘 要 】

This review examines the role of membrane rafts in neural disease as a rationale for drug targeting utilizing lipid-based nanoparticles. The article begins with an overview of methodological issues involving the existence, sizes, and lifetimes of rafts, and then examines raft function in the etiologies of three major neural diseases—epilepsy, Parkinson’s disease, and Alzheimer’s disease—selected as promising candidates for raft-based therapeutics. Raft-targeting drug delivery systems involving liposomes and solid lipid nanoparticles are then examined in detail.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.