Standard of Care and Promising New Agents for Triple Negative Metastatic Breast Cancer

Cancers

Patrizia Mancini²  Antonio Angeloni³  Emanuela Risi⁴  Errico Orsi¹ 

[1] Department of Surgical Science, Sapienza University of Rome, Viale Regina Elena 324, Rome 00161, Italy; E-Mail:;Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome 00161, Italy;Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome 00161, Italy; E-Mail:;Department of Radiology, Oncology and Human Pathology, Sapienza University of Rome, Viale Regina Elena 324, Rome 00161, Italy; E-Mails:

关键词: TNBC;    VEGF;    Aurora;    Hsp90;    PARP;    immunotherapy;    platinum salts;    EGFR;    PI3K/AKT;    androgen receptor;   

DOI  :  10.3390/cancers6042187

来源: mdpi

【 摘 要 】

Triple negative breast cancer (TNBC) is a cluster of heterogeneous diseases, all of them sharing the lack of expression of estrogen and progesterone receptors and HER2 protein. They are characterized by different biological, molecular and clinical features, including a poor prognosis despite the increased sensitivity to the current cytotoxic therapies. Several studies have identified important molecular features which enable further subdivision of this type of tumor. We are drawing from genomics, transcription and translation analysis at different levels, to improve our knowledge of the molecular alterations along the pathways which are activated during carcinogenesis and tumor progression. How this information should be used for the rational selection of therapy is an ongoing challenge and the subject of numerous research studies in progress. Currently, the vascular endothelial growth factor (VEGF), poly (ADP-ribose) polymerase (PARP), HSP90 and Aurora inhibitors are most used as targeting agents in metastatic setting clinical trials. In this paper we will review the current knowledge about the genetic subtypes of TNBC and their different responses to conventional therapeutic strategies, as well as to some new promising molecular target agents, aimed to achieve more tailored therapies.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.