Anticancer effects of plant derived Anacardic acid on human breast cancer MDA-MB-231 cells

American Journal of Translational Research

Wenxia Dong¹  Xiaosong Ge²  Qing Zhao³  Pei Zhang⁴  Haifeng Cai⁵  Dong Kong⁶  Xiaofeng Zhang⁷  Rong Liang⁸  Min Du⁹ 

[1] Department of Education and Nephrology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;Department of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;Department of Pharmacy, Bengbu Medical College, Anhui, Peoples Republic of China;Department of Pharmacy, The Fifth Peoples Hospital of Wuxi, Wuxi, Jiangsu, Peoples Republic of China;Department of Radiotherapy, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;Department of Respiration, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China;School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, Peoples Republic of China

关键词: Anacardic acid;    TNBC;    Hsp90;    ERS;    anticancer effect;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Triple negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers. It is a heterogeneous disease, characterized by early relapse, aggressive behavior, and poor prognosis, when compared to other breast cancer subtypes. Interestingly, most of the heat shock protein 90 (Hsp90) client proteins are oncoproteins, and some are closely related to the key factors that promote the progression of TNBC. Anacardic acid (AA), which is commonly seen in natural plants of Anacardiaceae, exhibits potent Hsp90 ATPase inhibition activity. In this study, the anticancer effects of AA on TNBC MDA-MB-231 cells were investigated. The results of our study showed that AA inhibited cell proliferation, induced G0/G1-phase cell cycle arrest, suppressed cell invasion and migration, and induced apoptosis in the MDA-MB-231 cells. Regulation of the key Hsp90-dependent tumor-related molecules or endoplasmic reticulum stress (ERS) related molecules, such as GRP78, Hsp70, CDK-4, MMP-9, Bcl-2, and Mcl-1 by AA may be related to these effects. Taken together, our results suggest that AA shows potential as a possible new drug for therapy of TNBC.

【 授权许可】

CC BY-NC