Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.

Molecules

Wei-Hua Jiao¹  Jing Li¹  Qian Liu³  Ting-Ting Xu¹  Guo-Hua Shi¹  Hao-Bing Yu²  Fan Yang¹  Bing-Nan Han¹  Min Li³  Hou-Wen Lin¹ 

[1] Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China; E-Mails:;Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; E-Mail:;Department of Clinical Laboratory, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China; E-Mails:

关键词: dysidinoid A;    meroterpenoid;    anti-MRSA;    Dysidea;    marine sponge;   

DOI  :  10.3390/molecules191118025

来源: mdpi

【 摘 要 】

An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) with MIC₉₀ values of 8.0 μg/mL against both.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.