Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.

Molecules

Min Li¹  Qian Liu¹  Wei-Hua Jiao²  Jing Li²  Ting-Ting Xu²  Guo-Hua Shi²  Hou-Wen Lin²  Fan Yang²  Bing-Nan Han²  Hao-Bing Yu³ 

[1] Department of Clinical Laboratory, Renji Hospital, School of Medicine,Shanghai Jiaotong University, Shanghai 200127, China;Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China;Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital,Second Military Medical University, Shanghai 200003, China;

关键词: dysidinoid A;    meroterpenoid;    anti-MRSA;    Dysidea;    marine sponge;   

DOI  :  10.3390/molecules191118025

来源: DOAJ

【 摘 要 】

An unusual meroterpenoid, dysidinoid A (1), was isolated from the South China Sea sponge Dysidea sp. Its structure was elucidated by extensive spectroscopic methods including HRESIMS and 2D NMR, and its absolute configuration was determined by single-crystal X-ray diffraction analysis. Dysidinoid A (1) is the first meroterpenoid from Nature bearing a 9,4-friedodrime skeleton and a 2,5-dionepyrrole unit. Dysidinoid A (1) showed potent antibacterial activity against two strains of pathogenic bacteriamethicillin-resistant Staphylococcus aureus (MRSA) with MIC90 values of 8.0 μg/mL against both.

【 授权许可】

Unknown