International Journal of Molecular Sciences | |
Synthesis, Docking and Biological Activities of Novel Hybrids Celecoxib and Anthraquinone Analogs as Potent Cytotoxic Agents | |
Maha S. Almutairi2  Gehan H. Hegazy4  Mogedda E. Haiba2  Hamed I. Ali5  Nagy M. Khalifa3  Abd El-mohsen M. Soliman1  | |
[1] Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Division, National Research Center, Dokki, Cairo 12622, Egypt; E-Mail:;Pharmaceutical Chemistry Department, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; E-Mails:;Pharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; E-Mail:;Department of Pharmaceutical Sciences, Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Kingsville, TX 78363, USA; E-Mail: | |
关键词: antitumor; anthraquinone; celecoxib; HEPG2; docking; protein kinase activities; | |
DOI : 10.3390/ijms151222580 | |
来源: mdpi | |
【 摘 要 】
Herein, novel hybrid compounds of celecoxib and 2-aminoanthraquinone derivatives have been synthesized using condensation reactions of celecoxib with 2-aminoanthraquinone derivatives or 2-aminoanthraquinon with celecoxib derivatives. Celecoxib was reacted with different acid chlorides, 2-chloroethylisocyanate and bis (2-chloroethyl) amine hydrochloride. These intermediates were then reacted with 2-aminoanthraquinone. Also the same different acid chlorides and 2-chloroethylisocyanate were reacted with 2-aminoanthraquinone and the resulting intermediates were reacted with celecoxib to give isomers for the previous compounds. The antitumor activities against hepatic carcinoma tumor cell line (HEPG2) have been investigated
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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